SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITIES OF2,6-DIARYLPIPERIDONE –y-DERIVATIVES

Kh. Hamak; F. Kandil; S. Hamo

doi:10.24996/iraqijournalofscience.v53i3.12732

Authors

Kh. Hamak Department of Chemistry , Faculty of Science, University of Damascus . Damascus-Syria
F. Kandil Department of Chemistry , Faculty of Science, University of Damascus . Damascus-Syria
S. Hamo Department of Chemistry , Faculty of Science, University of Damascus . Damascus-Syria

DOI:

https://doi.org/10.24996/iraqijournalofscience.v53i3.12732

Keywords:

piperidone-4 , imidazole , , Antibacterial activity, E.coli ,Bacillus subtilis

Abstract

In the present study new series of2,6-diarylpiperidones-4 derivative were synthesized and these compounds are :
1-(1-oxo-2-chloro-ethyl)-3,3-dimethyl-2.6-diarylpiperidone-4(I)
1-(1-oxo-2-chloro-ethyl)-3.5-dimethyl-2,6-diarylpiperidone-4(II)
1-(1-oxo-2-imidazolyl-ethyl) -3,3-dimethyl-2,6-diphenyl piperidoe-4(III)
1-(1-oxo-2-imidazolyl-ethyl)-3,5-dimethyl-2,6-diphenylpiperidoe-4 (IV)
The prepared compounds were characterized by IR,LC-MS and 1H,13C-NMR spectra .All compounds were screened for their antibacterial activity against gram positive bacteria :Bacillus subtilis and gram negative bacteria :Escherichia coli at different concentration (1000, 500, 250, 100) ppm. These compounds show good activity against gram positive more than gram negative bacteria